/* ==========================================
   PIK3CA project page: hero, stat row, charts, 3D viewers
   Chart colours are validated (scripts in the dataviz guide) against
   --paper in each theme; light and dark are stepped separately.
   ========================================== */

:root {
  --pk-c1: #00849c;   /* co-folding / crystal / TFG on */
  --pk-c2: #c24a32;   /* docking / prediction / TFG off */
  --pk-c3: #6b5bb5;   /* rescoring */
  --pk-c4: #a87a14;   /* sequence */
  --pk-c1-soft: rgba(0, 132, 156, 0.16);
  --pk-c2-soft: rgba(194, 74, 50, 0.13);
  --pk-grid: rgba(87, 81, 69, 0.18);
  --pk-pocket: #9f968a;
  --pk-cartoon: #b9b0a0;   /* protein in the structure viewers */
  --pk-tip-bg: #15120e;
  --pk-tip-ink: #f7f3ec;
}

:root[data-theme="dark"] {
  --pk-c1: #2ea3b3;
  --pk-c2: #de5a45;
  --pk-c3: #8f78de;
  --pk-c4: #b58a33;
  --pk-c1-soft: rgba(46, 163, 179, 0.2);
  --pk-c2-soft: rgba(222, 90, 69, 0.16);
  --pk-grid: rgba(139, 148, 163, 0.16);
  --pk-pocket: #6b7688;
  --pk-cartoon: #47526a;
  --pk-tip-bg: #e8e3d8;
  --pk-tip-ink: #0a0f16;
}

/* Hero */
.pk-hero {
  margin: 1.5rem 0 2.5rem;
}

.pk-kicker,
.pk-byline,
.pk-abstract-label,
.pk-tag,
.pk-btn,
.pk-key,
.pk-readout,
.pk-doc-meta,
.pk-plot text {
  font-family: var(--font-mono);
}

.pk-kicker {
  margin: 0 0 1rem;
  font-size: 0.75rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--seal);
}

.pk-title {
  margin: 0 0 1.1rem;
  font-family: var(--font-display);
  font-size: clamp(1.6rem, 3.8vw, 2.3rem);
  font-weight: 500;
  line-height: 1.08;
  letter-spacing: -0.01em;
  text-wrap: balance;
}

.pk-dek {
  max-width: 40em;
  margin: 0 0 1.1rem;
  font-size: 1.22rem;
  line-height: 1.5;
  color: var(--ink-soft);
}

.pk-byline {
  margin: 0 0 1.2rem;
  font-size: 0.78rem;
  color: var(--ink-soft);
}

.pk-byline a {
  border-bottom: 1px solid color-mix(in srgb, var(--seal) 55%, transparent);
}

.page ul.pk-links {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin: 0;
  padding: 0;
  list-style: none;
}

.page ul.pk-links li {
  margin: 0;
  padding: 0;
}

.page ul.pk-links li::before {
  content: none;
}

.pk-pill {
  display: inline-block;
  padding: 0.4rem 0.95rem;
  border: 1px solid var(--accent);
  border-radius: 999px;
  font-family: var(--font-mono);
  font-size: 0.8rem;
  text-decoration: none;
  color: var(--paper);
  background: var(--accent);
}

.pk-pill:hover {
  background: var(--accent-ink);
  border-color: var(--accent-ink);
  color: var(--paper);
}

.pk-pill--quiet {
  color: var(--accent);
  background: transparent;
}

.pk-pill--quiet:hover {
  color: var(--paper);
}

/* Stat row */
.pk-abstract {
  margin: 0 0 2.5rem;
  padding: 1.1rem 0 0.4rem;
  border-top: 1px solid var(--line);
  border-bottom: 1px solid var(--line);
}

.pk-abstract-label {
  margin: 0 0 0.6rem;
  font-size: 0.7rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--seal);
}

.pk-abstract p:not(.pk-abstract-label) {
  font-size: 0.98rem;
  color: var(--ink-soft);
}

.pk-tag {
  display: inline-block;
  padding: 0.05rem 0.45rem;
  border: 1px solid var(--seal);
  border-radius: 999px;
  font-size: 0.62rem;
  font-weight: 400;
  letter-spacing: 0.04em;
  line-height: 1.5;
  text-transform: uppercase;
  vertical-align: middle;
  white-space: nowrap;
  color: var(--seal);
}

.page > h2 .pk-tag {
  margin-left: 0.3rem;
  font-size: 0.6rem;
}

/* Figures */
.pk-figure {
  margin: 2rem 0 2.4rem;
}

.pk-figure figcaption {
  margin-top: 0.7rem;
  font-size: 0.9rem;
  line-height: 1.5;
  color: var(--ink-soft);
}

.pk-figure img {
  display: block;
  width: 100%;
  height: auto;
}

/* The ChimeraX render has a white background; give it a paper card in both themes. */
.pk-figure--paper img {
  padding: 0.6rem;
  border-radius: var(--radius);
  background: #ffffff;
}

.pk-split {
  display: grid;
  grid-template-columns: minmax(0, 1.25fr) minmax(0, 1fr);
  gap: 2rem;
  align-items: start;
}

.pk-split > div > p:first-child {
  margin-top: 0;
}

.pk-split .pk-figure {
  margin: 0.3rem 0 0;
}

/* Controls */
.pk-controls {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-bottom: 0.9rem;
}

.pk-btn {
  min-height: 32px;
  padding: 0.3rem 0.8rem;
  border: 1px solid var(--line);
  border-radius: 999px;
  font-size: 0.74rem;
  color: var(--ink-soft);
  background: transparent;
  cursor: pointer;
}

.pk-btn:hover {
  border-color: var(--ink-soft);
  color: var(--ink);
}

.pk-btn.is-on {
  border-color: var(--ink);
  color: var(--paper);
  background: var(--ink);
}

.pk-btn:focus-visible,
.pk-scrub:focus-visible {
  outline: 2px solid var(--accent);
  outline-offset: 2px;
}

/* Legends */
.pk-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 6px 18px;
  margin-bottom: 0.6rem;
}

.pk-key {
  display: inline-flex;
  align-items: center;
  gap: 7px;
  font-size: 0.72rem;
  color: var(--ink-soft);
}

.pk-sw {
  display: inline-block;
  width: 11px;
  height: 11px;
  border-radius: 3px;
  background: var(--sw, var(--ink-soft));
}

.pk-sw--dot {
  border-radius: 50%;
}

.pk-sw--ring {
  border-radius: 50%;
  border: 2px solid var(--sw);
  background: transparent;
}

.pk-sw--crystal { --sw: var(--pk-c1); }
.pk-sw--pred { --sw: var(--pk-c2); }
.pk-sw--pocket { --sw: var(--pk-pocket); }

/* SVG charts */
.pk-plot {
  position: relative;
  width: 100%;
}

.pk-plot svg {
  display: block;
  width: 100%;
  height: auto;
  overflow: visible;
}

.pk-plot text {
  font-size: 11px;
  fill: var(--ink-soft);
}

.pk-plot .t-strong {
  fill: var(--ink);
}

.pk-plot .t-tag {
  fill: var(--seal);
  font-size: 9.5px;
  letter-spacing: 0.04em;
}

.pk-plot .grid {
  stroke: var(--pk-grid);
  stroke-width: 1;
}

.pk-plot .axis {
  stroke: var(--line);
  stroke-width: 1;
}

.pk-plot .zero {
  stroke: var(--ink-soft);
  stroke-width: 1;
  opacity: 0.6;
}

.pk-plot .thresh {
  stroke: var(--ink-soft);
  stroke-width: 1;
  stroke-dasharray: 4 4;
}

.pk-plot .band {
  fill: var(--surface);
}

.pk-plot .ci {
  stroke-width: 2;
  stroke-linecap: round;
  opacity: 0.55;
}

.pk-plot .dot {
  stroke: var(--paper);
  stroke-width: 2;
}

.pk-plot .dot.open {
  fill: var(--paper);
  stroke-width: 2;
}

.pk-plot .f-cofold { fill: var(--pk-c1); stroke: var(--pk-c1); }
.pk-plot .f-dock { fill: var(--pk-c2); stroke: var(--pk-c2); }
.pk-plot .f-rescore { fill: var(--pk-c3); stroke: var(--pk-c3); }
.pk-plot .f-seq { fill: var(--pk-c4); stroke: var(--pk-c4); }
.pk-plot .dot.f-cofold, .pk-plot .dot.f-dock, .pk-plot .dot.f-rescore, .pk-plot .dot.f-seq { stroke: var(--paper); }
.pk-plot .dot.open.f-cofold { stroke: var(--pk-c1); }
.pk-plot .dot.open.f-dock { stroke: var(--pk-c2); }

.pk-plot .q-ok {
  fill: var(--pk-c1-soft);
}

.pk-plot .hit {
  fill: transparent;
  cursor: default;
}

.pk-plot .row-hover {
  fill: var(--surface);
  opacity: 0;
}

.pk-plot g.row:hover .row-hover {
  opacity: 1;
}

/* Matrix cells */
.pk-plot .c-biochemical { fill: var(--pk-c1); }
.pk-plot .c-weaker { fill: var(--pk-c1-soft); stroke: var(--pk-c1); stroke-width: 1; }
.pk-plot .c-negative { fill: var(--pk-c2-soft); }
.pk-plot .c-excluded { fill: var(--surface); }
.pk-plot rect.cell:hover { stroke: var(--ink); stroke-width: 1.5; }

/* Tooltip */
.pk-tip {
  position: fixed;
  z-index: 60;
  max-width: 260px;
  padding: 0.45rem 0.6rem;
  border-radius: 4px;
  font-family: var(--font-mono);
  font-size: 0.72rem;
  line-height: 1.45;
  color: var(--pk-tip-ink);
  background: var(--pk-tip-bg);
  pointer-events: none;
  opacity: 0;
  transform: translate(-50%, calc(-100% - 10px));
  transition: opacity 0.12s ease;
}

.pk-tip.is-on {
  opacity: 1;
}

.pk-tip b {
  font-weight: 500;
}

/* 3D viewers */
.pk-viewer {
  position: relative;
  width: 100%;
  height: 440px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: var(--surface);
  overflow: hidden;
  touch-action: none;
}

.pk-viewer--short {
  height: 380px;
}

.pk-viewer-msg {
  position: absolute;
  inset: 0;
  display: grid;
  place-items: center;
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--ink-soft);
}

.pk-viewer-bar {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 10px 18px;
  margin-top: 0.7rem;
}

.pk-viewer-bar .pk-btn:first-child:not([data-action="play"]),
.pk-viewer-bar .pk-key + .pk-btn {
  margin-left: auto;
}

.pk-viewer-bar--keys {
  margin-top: 0.4rem;
}

.pk-play {
  min-width: 68px;
}

.pk-scrub {
  flex: 1;
  min-width: 140px;
  accent-color: var(--pk-c2);
}

.pk-readout {
  font-size: 0.74rem;
  color: var(--ink-soft);
  font-variant-numeric: tabular-nums;
}

.pk-spark {
  margin-top: 0.4rem;
}

.pk-spark svg {
  display: block;
  width: 100%;
  height: 54px;
  overflow: visible;
}

.pk-spark .line {
  fill: none;
  stroke: var(--pk-c2);
  stroke-width: 2;
  stroke-linejoin: round;
}

.pk-spark .now {
  fill: var(--pk-c2);
  stroke: var(--paper);
  stroke-width: 2;
}

.pk-spark .grid {
  stroke: var(--pk-grid);
}

.pk-spark text {
  font-family: var(--font-mono);
  font-size: 10px;
  fill: var(--ink-soft);
}

/* Thesis link card */
.pk-doc {
  margin: 0 0 1.6rem;
}

.pk-doc-link {
  display: flex;
  flex-direction: column;
  gap: 4px;
  padding: 1rem 1.2rem;
  border: 1px solid var(--line);
  border-left: 3px solid var(--seal);
  border-radius: var(--radius);
  text-decoration: none;
}

.pk-doc-link:hover {
  background: var(--surface);
}

.pk-doc-title {
  font-family: var(--font-display);
  font-size: 1.15rem;
  color: var(--ink);
}

.pk-doc-meta {
  font-size: 0.72rem;
  color: var(--ink-soft);
}

.pk-note {
  font-family: var(--font-mono);
  font-size: 0.8rem;
  color: var(--ink-soft);
}

@media (max-width: 760px) {
  .pk-split {
    grid-template-columns: 1fr;
  }

  .pk-viewer {
    height: 340px;
  }

  .pk-viewer--short {
    height: 300px;
  }
}

@media print {
  .pk-viewer-wrap,
  .pk-controls {
    display: none;
  }
}

.pk-mol {
  position: absolute;
  inset: 0;
}

/* Pose explorer and similarity charts */
.pk-controls--tools .pk-btn {
  display: inline-flex;
  align-items: center;
  gap: 7px;
}

.pk-controls--tools .pk-btn.is-on {
  border-color: var(--ink-soft);
  color: var(--ink);
  background: var(--surface);
}

.pk-controls--tools .pk-btn:not(.is-on) .pk-sw {
  opacity: 0.25;
}

.pk-btn[disabled] {
  opacity: 0.35;
  cursor: not-allowed;
}

.pk-controls-label {
  align-self: center;
  margin-right: 2px;
  font-family: var(--font-mono);
  font-size: 0.68rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--ink-soft);
}

.pk-sw--crystal-ink { --sw: var(--ink); }
.pk-sw--square { border-radius: 1px; }
.pk-sw--diamond { width: 10px; height: 10px; border-radius: 1px; transform: rotate(45deg); }
.pk-sw--triangle { border-radius: 0; clip-path: polygon(50% 0, 100% 100%, 0 100%); }
.pk-sw--plus { border-radius: 0; clip-path: polygon(38% 0, 62% 0, 62% 38%, 100% 38%, 100% 62%, 62% 62%, 62% 100%, 38% 100%, 38% 62%, 0 62%, 0 38%, 38% 38%); }
.pk-sw--cross { border-radius: 0; transform: rotate(45deg); clip-path: polygon(38% 0, 62% 0, 62% 38%, 100% 38%, 100% 62%, 62% 62%, 62% 100%, 38% 100%, 38% 62%, 0 62%, 0 38%, 38% 38%); }

.pk-plot .divider {
  stroke: var(--paper);
  stroke-width: 2;
}

.pk-plot .mark-line {
  fill: none;
  stroke-width: 2.5;
  stroke-linecap: round;
}

.pk-two {
  display: grid;
  grid-template-columns: minmax(0, 1.1fr) minmax(0, 1fr);
  gap: 1.5rem;
  align-items: start;
}

.pk-two h4 {
  margin: 0 0 0.6rem;
  font-family: var(--font-mono);
  font-size: 0.72rem;
  font-weight: 400;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--ink-soft);
}

.pk-narrow-only {
  display: none;
}

@media (max-width: 760px) {
  .pk-two {
    grid-template-columns: 1fr;
  }

  .pk-narrow-only {
    display: inline;
  }
}